EPHEDRINE BASE ANHYDROUS

PRODUCT IDENTIFICATION
CAS NO.

299-42-3

EPHEDRINE BASE ANHYDROUS
EINECS NO. 206-080-5
FORMULA C6H5CH[CH(NHCH3)CH3]OH
MOL WT. 165.23

H.S. CODE

  

TOXICITY

  
SYNONYMS L-(-)-Ephedrine; Efedrina; (1R,2S)-(-)-Ephedrine;
(-)-2-Methylamino-1-phenyl-propane-1-ol; alpha-[1-(methylamino)ethyl]benzyl alcohol; [R-(R',S')] alpha-[1-(methylamino)ethyl] Benzenemethanol; L-alpha-(1-Methylaminoethyl)benzyl alcohol; (1R,2S)-2-Methylamino-1-phenyl-1-propanol;
DERIVATION

 

CLASSIFICATION

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE Clear to pale yellow viscous liquid
MELTING POINT 36 C
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER Soluble (soluble in alcohol)
pH 4.5 - 6
VAPOR DENSITY

 
AUTOIGNITION

 
NFPA RATINGS  

REFRACTIVE INDEX

  
FLASH POINT  
STABILITY

Stable under ordinary conditions.

GENERAL DESCRIPTION & APPLICATIONS
Ephedrine is a sympathomimetic alkaloid originally obtained from species of Ephedra or prepared synthetically. Its action is similar to that of epinephrine (a catecholamine hormone secreted by the adrenal medulla and a neurotransmitter). Its effects, although less powerful, are more prolonged, and it exerts action when administered orally, whereas epinephrine is effective only by injection. It is used as muscle relaxants, central nervous system and cardiac muscle stimulants in combination with others like theophylline. It is used to prevent hypotension during spinal and infiltration anesthesia; and as a mydriatic. There are enantiomers in ephedrine structure. (1R,2S)- and (1S,2R)-enantiomers are designated ephedrine (opposite stereoisomerisms around the chiral center), whereas (1R,2R)- and (1S,2S)-enantiomers are designated pseudoephedrine. Commercial ephedrine is (-)-(1R,2S)-ephedrine [also called (-)-Ephedrine or L-ephedrine], while commercial pseudoephedrine enantiomer is (1S,2S)-pseudoephedrine [(+)-pseudoephedrine or D-pseudoephedrine]. Pseudoephedrine has less pressor action and fewer central stimulant effects than ephedrine. Pseudoephedrine is used as a nasal decongestant and a bronchodilator to relaxe and open the air passages to the lung to increase the flow of air, and thus is used in the treatment and/or prevention of symptoms of bronchial asthma and of reversible bronchospasm associated with chronic bronchitis and emphysema.

SALES SPECIFICATION

APPEARANCE

 Clear to pale yellow viscous liquid

IDENTIFICATION

passes test A,B
ASSAY

99.0.% - 101.0%

RELATED SUBSTANCE

0.5% max

OPTICAL ROTATION

-40.3° ~ -43.3° (C=2.5% in 0.6N HCL)

SOLVENT RESIDUE

 2500ppm max (Diisopropyl ether)

HEAVY METALS

20ppm max

WATER

0.5% max
CHLORIDE
5ppm max
TRANSPORTATION
PACKING
 
HAZARD CLASS  
UN NO.  
OTHER INFORMATION
Hazard Symbols: XN, Risk Phrases: 22, Safety Phrases: 22-23